Radioimmunotherapy of Metastatic Disease
نویسنده
چکیده
منابع مشابه
Radiommunotherapy and prostate cancer: a promising new therapy in the management of metastatic disease.
The mainstay of treatment for metastatic prostate cancer is androgen deprivation, but unfortunately all patients eventually become resistant to this treatment, developing androgen-independent cancer, with a median time to death of ≈1 year. In addition, taxanebased chemotherapy has met with limited success and is usually associated with significant toxicity. Recent research has suggested that ra...
متن کاملRadiolabelled monoclonal antibodies in the treatment of metastatic cancer
Most cancer patients die from advanced, metastatic disease. Because surgery and external irradiation are the best prospects for treating localized disease (although both have also been applied to limited treatment of metastatic disease), systemic chemotherapy—and more recently, immunotherapy—are the mainstays of treating cancer that has become disseminated. Systemic chemotherapy is accompanied ...
متن کاملEnhancement of the therapeutic index: from nonmyeloablative and myeloablative toward pretargeted radioimmunotherapy for metastatic prostate cancer.
PURPOSE New strategies that target selected molecular characteristics and result in an effective therapeutic index are needed for metastatic, hormone-refractory prostate cancer. EXPERIMENTAL DESIGN A series of preclinical and clinical studies were designed to increase the therapeutic index of targeted radiation therapy for prostate cancer. (111)In/90Y-monoclonal antibody (mAb), m170, which ta...
متن کاملReview of Salvage Therapy for Biochemically Recurrent Prostate Cancer: The Role of Imaging and Rationale for Systemic Salvage Targeted Anti-Prostate-Specific Membrane Antigen Radioimmunotherapy
Despite local therapy with curative intent, approximately 30% of men suffer from biochemical relapse. Though some of these PSA relapses are not life threatening, many men eventually progress to metastatic disease and die of prostate cancer. Local therapy is an option for some men, but many have progression of disease following local salvage attempts. One significant issue in this setting is the...
متن کاملRadioimmunotherapy for colorectal cancer.
Monoclonal antibodies, selected for their ability to recognize and bind tumor-specific antigens, are a promising vehicle for systemic antitumor therapy. Radioimmunotherapy utilizes radioisotopes conjugated to monoclonal antibodies to deliver tumoricidal radiation doses. In the >20 years since radioimmunotherapy began, many obstacles to successful application of this antitumor modality have been...
متن کامل